current research


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374. Barrientos LG, Matei E, Lasala F, Delgado R,  Gronenborn AM. Dissecting carbohydrate-Cyanovirin-N binding by structure-guided mutagenesis: Functional implications for viral entry inhibition. Protein Eng Des Sel 19 (12): 525-535 (2006).

375. Toptygin D, Gronenborn AM, Brand L.  Nanosecond relaxation dynamics of protein GB1 identified by the time dependent red shift in the fluorescence of tryptophan and 5 fluorotryptophan. J Phys Chem B 110:(51): 26292-26302 (2006).

376. Vega-Rocha S, Gronenborn AM, Gronenborn B, Campos-Olivas R. (1)H, (13)C, and (15)N NMR assignment of the master Rep protein nuclease domain from the Nanovirus FBNYV. J Biomol NMR 38(2):169 (2007).

377. Ermolenko DN, Dangi B, Gvritishvili A, Gronenborn AM, Makhatadze GI. Elimination of the C-cap in ubiquitin – structure, dynamics and thermodynamic consequences. Biophys Chem 126: 25-35 (2007).

378. Vega-Rocha S, Byeon I-JL, Gronenborn B, Gronenborn AM, Campos-Olivas R. Solution structure, divalent metal and DNA binding of the endonuclease domain from the replication initiation protein from Porcine Circovirus 2. J Mol Biol 367: 473-487 (2007).

379. Vega-Rocha S, Gronenborn B, Gronenborn AM, Campos-Olivas, R. Solution structure of the endonuclease domain from the master replication initiator protein of the Nanovirus Faba Bean Necrotic Yellows Virus and comparison with the corresponding Geminivirus and Circovirus structures. Biochemistry 46: 6201-6212 (2007).

380. Yang LW, Eyal E, Chennubhotla C, Jee J, Gronenborn AM, Bahar I. Insights into equilibrium dynamics of proteins from comparison of NMR and X-ray data with computational predictions. Structure 15(6): 741-749 (2007).

381. Shahkhatuni AA, Shahkahatuni AG, Panosyan HA, Shakyan AB, Byeon IJ, Gronenborn AM. Asssessment of solvent effects:  Do weak alignment media affect the structure of the solute? Magn Reson Chem 45(7): 557-563 (2007).

382. Iwatani Y, Chan DS, Wang F, Maynard KS, Sugiura W, Gronenborn AM, Rouzina I, Williams MC, Musier-Forsyth K, Levin JG. Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G. Nucleic Acids Res 35: 7096-7108 (2007).

383.Sandström C, Hakkarainen B, Matei E, Glinchert A, Lahmann M, Oscarson S, Kenne L, Gronenborn AM. Atomic mapping of the sugar interactions in one-site and two-site mutants of Cyanovirin-N by NMR spectroscopy. Biochemistry 47: 3625-3635 (2008).

384. Jee J, Ishima R, Gronenborn AM. Characterization of specific protein association by 15N CPMG relaxation dispersion NMR: The GB1A34F monomer-dimer equilibrium. J Phys Chem B 112: 6008-6012 (2008).

385. Jee J, Byeon I-J, Louis JM, Gronenborn AM. The point mutation A34F causes dimerization of GB1. Proteins 71: 1420-1431 (2008).

386. Koharudin LMI, Viscomi AR, Jee J-G, Ottonello S, Gronenborn AM. The evolutionary conserved family of Cyanovirin-N homologs (CVNHs):  Structures and carbohydrate specificity. Structure 16: 570-584 (2008).

387. Matei E, Furey W, Gronenborn AM. Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: No evidence of domain swapping. Structure 16: 1183-1194 (2008) PMC2637156.

388. Wang X, Fukuda K, Byeon I-J, Velyvis A, Wu C, Gronenborn AM, Qin J. Structure of a-parvin CH2/paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. J Biol Chem 283(30): 21113-9 (2008) PMC2475713.

389. Ahn J, Byeon I-J, Byeon CH, Gronenborn AM. Insight into the structural basis of pro- and anti-apoptotic p53 modulation by ASPP proteins. J Biol Chem 284: 13812-13822 (2009) PMC2679482.

390. Jung J, Byeon IL, Wang Y, King J, Gronenborn AM. The structure of the cataract-causing P23T mutant of human gD-crystallin exhibits distinctive local conformational and dynamic changes. Biochemistry 48: 2597-2609 (2009) PMC2722838.

391. Thakur AK, Jayaraman M, Mishra R, Thakur M, Chellgren VM, Byeon IL, Anjum DH, Kodali R, Creamer TP, Conway JF, Gronenborn AM, Wetzel R. Polyglutamine disruption of the huntingtin exon1 N-terminus triggers a complex aggregation mechanism. Nat Struct Mol Biol 16(4): 380-389 (2009) PMC2706102.

392. Gronenborn AM. Protein acrobatics in pairs – dimerization via domain swapping. Curr Opin Struct Biol 19(1): 39-49 (2009) PMC2676429.

393. Koharudin LMI, Furey W, Liu H, Liu YJ, Gronenborn AM. The Phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). J Biol Chem 284: 23697-23707 (2009; selected as paper of the week) PMC2749144.

394. Wang J, Zuo X, Yu P, Byeon IL, Jung J, Wang X, Dyba M, Seifert S, Schwieters CD, Qin J, Gronenborn AM, Wang Y. Determination of multicomponent protein structures in solution using global orientation and shape restraints. J Am Chem Soc 131: 10507-10515 (2009) PMC2873192.

395. Koharudin LMI, Furey W, Gronenborn AM. A designed chimeric cyanovirin-N homolog lectin: structure and molecular basis of sucrose binding. Proteins 77: 904-915 (2009) PMC2773468.

396. Liu L, Koharudin LMI, Gronenborn AM, Bahar I. A comparative analysis of the equilibrium dynamics of a designed protein inferred from NMR, X-ray, and computations. Proteins 77: 927-39 (2009) PMC2767477.

Iwatani, Y, Chan, DSB, Liu, L, Yoshii, H, Shibata, J, Yamamoto, N, Levin, JG, Gronenborn, AM, Sugiura, W. HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain. Proc. Natl. Acad. Sci. U.S.A. 17, 19539-19544, 2009, PMC2772817