current research

Gallery

1olg 3eza 2L9Y

2012 – 2013

421. Kilpatrick AM, Koharudin LM, Calero GA, Gronenborn AM. Structural and binding studies of the C-terminal domains of yeast TFIIF subunits Tfg1 and Tfg2. Proteins 80: 519–529 (2012).

422. Liu L, Gronenborn AM, Bahar I. Longer simulations sample larger subspaces of conformations while maintaining robust mechanisms of motion. Proteins 80: 616–25 (2012) PMC329068.

423. Jayaraman M, Mishra R, Kodali R, Thakur A, Koharudin L, Gronenborn AM, Wetzel R. Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties.  Biochemistry 51: 2706-2716 (2012) PMC3394396.

424. Ji F, Jung J, Gronenborn AM.  Structural and biochemical characterization of the childhood cataract-associated R76S mutant of human gD-crystallin.  Biochemistry 51(12): 2588-2596 (2012) PMC3326406.

425. Byeon I-JL, Hou G, Han Y, Suiter CL, Ahn J, Jung J, Byeon C-H, Gronenborn AM, Polenova T. Motions on the millisecond timescale and multiple conformations of HIV-1 capsid protein: Implications for structural polymorphism of CA assemblies. J Am Chem Soc 134 (14): 6455-6466 (2012) PMC3325613.

426. Sun S, Paramasivam S, Yan S, Han Y, Lightcap C, Williams JC, Byeon I-JL, Ahn J, Gronenborn AM, Polenova T. Solid-State NMR of protein complexes. Methods Mol Biol 831: 303-331 (2012).

427. Liu L, Byeon I-J, Bahar I, Gronenborn AM. Domain swapping proceeds via complete unfolding: A 19F- and 1H NMR study of the cyanovirin-N protein.  J Am Chem Soc 134: 4229−4235 (2012) PMC3326405.

428. Wang X, Matei E, Gronenborn AM, Ramstrom O, Yan M. Direct measurement of glyconanoparticles and lectin interactions by Isothermal Titration Calorimetry. Anal Chem 84: 4248-4252 (2012) PMC3526666.

429. Yang R, Shi J, Byeon I-J, Ahn J, Sheehan JH, Meiler J, Gronenborn AM, Aiken C. Second-site suppressors of  HIV-1 capsid mutations:  restoration of intracellular activities without correction of intrinsic capsid stability defects.  Retrovirology 9 (30): 1-14 (2012) PMC3351742.

430. Meng X, Zhao G, Yufenyuy E, Ke D, Ning J, DeLucia M, Ahn J, Gronenborn AM, Aiken C, Zhang P. Protease cleavage leads to formation of mature trimer interface in HIV-1 capsid.  PLoS Pathogens 8(8):e10028862012 (2012) PMC3426514.

431. Koharudin LMI, Kollipara S, Aiken C, Gronenborn AM. Structural insights into the anti-HIV activity of the oscillatoria agardhii agglutinin homolog lectin family.  J Biol Chem 287, 33796-811  (2012)  PMC3460475.

432. Yang H, Ji X, Zhao G, Ning J, Zhao Q, Aiken C, Gronenborn AM, Zhang P, Xiong Y. Structural insight into HIV-1 capsid recognition by rhesus TRIM5α. Proc Natl Acad Sci USA 109(45): 18372-7 (2012) PMC3494900.

433. Hou G, Byeon IJ, Ahn J, Gronenborn AM, Polenova T. Recoupling of chemical shift anisotropy by R-symmetry sequences in magic angle spinning NMR spectroscopy. J Chem Phys 137(13): 134201 (2012) PMC3477183.

434. Krzysiak TC, Jung J, Thompson J, Baker D, Gronenborn AM. APOBEC2 is a monomer in solution: implications for APOBEC3G models. Biochemistry 51(9):2008-17 (2012)  PMC3316327.

435. Ahn J, Hao C, Yan J, DeLucia M, Mehrens J, Wang C, Gronenborn AM, Skowronski J.  HIV/Simian Immunodeficiency Virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.  J Biol Chem 287(15): 12550-12558 (2012) PMC3321004.

436. Ji F, Jung J, Koharudin LM, Gronenborn AM. The human W42R γD-crystallin mutant structure provides a link between congenital and age-related cataracts. J Biol Chem 288 (1):99-109 (2013) PMC3537076.

437. Koharudin LMI, Gronenborn AM.  Sweet entanglements-protein: Glycan interactions in two HIV-inactivating lectin families.  Biopolymers 99 (3):196-202 (2013) PMC3535575.

438. Koharudin LM, Boelens R, Kaptein R, Gronenborn AM. A NMR guided approach for CsrA-RNA crystallization. J Biomol NMR 56(1):31-9 (2013)

439. Yan J, Kaur S, Delucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J, Skowronski J. Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem 288(15):10406-17 (2013) PMC3624423

440. Matei E, André S, Glinschert A, Infantino AS, Oscarson S, Gabius HJ, Gronenborn AM. Fluorinated Carbohydrates as Lectin Ligands: Dissecting Glycan-Cyanovirin Interactions by Using 19 F NMR Spectroscopy. Chemistry 19(17):5364-74 (2013) PMC3796943

441. Whitley MJ, Furey W, Kollipara S, Gronenborn AM. Burkholderia oklahomensis agglutinin is a canonical two-domain OAA-family lectin: structures, carbohydrate binding, and anti-HIV activity. FEBS J 280(9):2056-67 (2013) PMC3745830

442. Wang X, Matei E, Deng L, Koharudin L, Gronenborn AM, Ramström O, Yan M. Sensing lectin-glycan interactions using lectin super-microarrays and glycans labeled with dye-doped silica nanoparticles. Biosens Bioelectron 47:258-64 (2013) PMC3661755

443. Koharudin LM, Liu L, Gronenborn AM. Different 3D domain-swapped oligomeric cyanovirin-N structures suggest trapped folding intermediates. Proc Natl Acad Sci U S A 110(19):7702-7 (2013) PMC3651430

444. Byeon IJ, Ahn J, Mitra M, Byeon CH, Hercík K, Hritz J, Charlton LM, Levin JG, Gronenborn AM. NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity.  Nat Commun 4:1890 (2013) PMC3674325

445. Zhao G, Perilla JR, Yufenyuy EL, Meng X, Chen B, Ning J, Ahn J, Gronenborn AM, Schulten K, Aiken C, Zhang P. Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics. Nature 497(7451):643-646 (2013) PMC3729984

446. Ji F, Koharudin LM, Jung J, Gronenborn AM. Crystal structure of the cataract-causing P23T γD-crystallin mutant. Proteins 81(9): 1493-8 (2013) PMC3852438

447. Ban D, Mazur A, G Carneiro M, Sabo TM, Giller K, Koharudin LM, Becker S, Gronenborn AM, Griesinger C, Lee D. Enhanced accuracy of kinetic information from CT-CPMG experiments by transverse rotating-frame spectroscopy. J Biomol NMR 57(1):73-82 (2013)

448. Ji X, Wu Y, Yan J, Mehrens J, Yang H, Delucia M, Hao C, Gronenborn AM, Skowronski J, Ahn J, Xiong Y.  Mechanism of allosteric activation of SAMHD1 by dGTP. Nat Struct Mol Biol 20(11):1304-9 (2013). PMC3833828

449. Han Y, Hou G, Suiter CL, Ahn J, Byeon IJ, Lipton AS, Burton SD, Hung I, Gor’kov PL, Gan Z, Brey WW, Rice D, Gronenborn AM, Polenova TE. Magic angle spinning NMR reveals sequence-dependent structural plasticity, dynamics, and the spacer peptide 1 conformation in HIV-1 capsid protein assemblies. J Am Chem Soc 135(47):17793-803 (2013). PMC3928671