current research

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1olg 1wjc 2k2r

2023-2024

531. Zhu W, Yang DT, Gronenborn AM. Ligand-Capped Cobalt(II) Multiplies the Value of the Double-Histidine Motif for PCS NMR Studies. J Am Chem Soc. 2023 Mar 1;145(8):4564-4569. doi: 10.1021/jacs.2c12021. Epub 2023 Feb 14. PMID: 36786809.

532. Sarkar S, Zadrozny KK, Zadorozhnyi R, Russell RW, Quinn CM, Kleinpeter A, Ablan S, Meshkin H, Perilla JR, Freed EO, Ganser-Pornillos BK, Pornillos O, Gronenborn AM, Polenova T. Structural basis of HIV-1 maturation inhibitor binding and activity. Nat Commun. 2023 Mar 4;14(1):1237. doi: 10.1038/s41467-023-36569-y. PMID: 36871077; PMCID: PMC9985623.

533. Seal M, Zhu W, Dalaloyan A, Feintuch A, Bogdanov A, Frydman V, Su XC, Gronenborn AM, Goldfarb D. GdIII -19F Distance Measurements for Proteins in Cells by Electron-Nuclear Double Resonance. Angew Chem Int Ed Engl. 2023 May 8;62(20):e202218780. doi: 10.1002/anie.202218780. PMID: 36905181.

534. Bai XC, Gonen T, Gronenborn AM, Perrakis A, Thorn A, Yang J. Challenges and opportunities in macromolecular structure determination. Nat Rev Mol Cell Biol. 2024 Jan;25(1):7-12. doi: 10.1038/s41580-023-00659-y. Epub 2023 Oct 17. PMID: 37848590.

535. Zadorozhnyi R, Gronenborn AM, Polenova T. Integrative approaches for characterizing protein dynamics: NMR, CryoEM, and computer simulations. Curr Opin Struct Biol. 2023 Dec 3;84:102736. doi: 10.1016/j.sbi.2023.102736. PMID: 38048753.

536. Heath SL, Guseman AJ, Gronenborn AM, Horne WS. Probing Effects of Site-Specific Aspartic Acid Isomerization on Structure and Stability of GB1 through Chemical Protein Synthesis. Protein Sci. 2024 Mar;33(3):e4883. doi: 10.1002/pro.4883. PMID: 38143426; PMCID: PMC10868458.

537. Bogdanov A, Frydman V, Seal M, Rapatskiy L, Schnegg A, Zhu W, Iron M, Gronenborn AM, Goldfarb D. Extending the range of distances accessible by 19F electron-nuclear double resonance in proteins using high-spin Gd(III) labels. J Am Chem Soc. 2024 Mar 6;146(9):6157-6167. doi: 10.1021/jacs.3c13745. Epub 2024 Feb 23. PMID: 38393979; PMCID: PMC10921402.

538. Krzysiak TC, Choi YJ, Kim YJ, Yang Y, DeHaven C, Thompson L, Ponticelli R, Mermigos MM, Thomas L, Marquez A, Sipula I, Kemper JK, Jurczak M, Thomas G, Gronenborn AM. Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification. Protein Sci. 2024 Apr;33(4):e4938. doi: 10.1002/pro.4938. PMID: 38533551; PMCID: PMC10966392.